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Hepatic CP activity was significantly lower in Aadac KO mice than that in WT mice, resulting in elevated hepatic ferrous iron levels in Aadac KO mice

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In the United States alone, APAP misuse accounts for approximately 500 deaths annually, in addition to nearly 100,000 poisoning-related emergency calls, 50,000 emergency department visits, and 10,000 hospitalizations (67)