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Gaballa SA, et al

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10.1007/s00281-013-0384-6 Semin

Research indicates that Protein tyrosine kinase 2 (PTK2) stimulates the accumulation of -catenin in the nucleus of HCC cells, thereby increasing Wnt/-catenin signaling pathway activity, and in this way promoting stemness of CSCs and enhancing the tumorigenicity of HCC cells (109)