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The inhibition of these deleterious AT 1 receptor-mediated effects through ACE inhibitors or Ang receptor blockers (and more recently the direct renin inhibitor aliskiren) largely explains as to why the two former classes of antihypertensive drugs have become the gold standard of antihypertensive therapy

The same studies can be located independently on PubMed using the CAS number (1401708-83-5) or the compound name