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Casadevall, A

759 The E3 ligase RING finger protein 146 (RNF146) is responsible for ubiquitination and degradation of ACSL4

The higher activity in the maternal transsulfuration pathway in early pregnancy is probably a compensatory reaction in response to the high demands for cysteine during the fetal development coupled with the inability of the fetus to synthesise cysteine on its own due to the absence of transsulfuration activity in the fetal liver (Reference Kalhan and Bier51)