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There are, however, not only successes to be counted, as late 2023 saw termination of the clinical development of VYVGART within pemphigus vulgaris and pemphigus foliaceus on account of the phase III ADDRESS trial missing its primary endpoint [254].) While VYVGART did reduce both total IgG and autoreactive DsG-targeting IgG by up to 75%, it did not lead to a sufficient clinical benefit compared to standard-of-care treatment with corticosteroids

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