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We thank all synonymous reviewers for their valuable comments on the peer review of this work

Xc is inhibited directly by erastin or its more potent analogs imidazole ketone erastin (IKE) and piperazine erastin (PE), or indirectly by sorafenib or high extracellular glutamate concentrations.7,23 However, some cells use the transsulfuration pathway to synthesize cysteine becoming resistant to Xc inhibitors.24 Moreover, buthionine-(S, R)-sulfoximine (BSO), an inhibitor glutamate-cysteine ligase, interferes with GSH synthesis and can also promote ferroptosis.25 Molecular mechanisms of ferroptosis

Development of a questionnaire and screening model for lipedema

99% purity, HPLC verified