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The triptan drugs (e.g., sumatriptan, rizatriptan, eletriptan, and almotriptan) act on several specific mechanisms of a migraine headache, such as promoting vasoconstriction and blocking pain pathways in the brainstem

J Mol Cell Cardiol 125:185194 Zhong J, Tan Y, Lu J, Liu J, Xiao X, Zhu P et al (2019) Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: a novel mechanism linking Ripk3-modified mitochondrial performance and Endoplasmic reticulum function