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Over time, particulate matter, biofilm, and other debris accumulate on the surface and within the GAC media, leading to increased headloss, reduced flow capacity, and diminished filtration efficiency

Co-trimoxazole is a US Food and Drug Administration-approved drug consisting of two antifolates, trimethoprim and sulfamethoxazole, which are on the list of the World Health Organization essential medicines that have been used as effective antimicrobial agents for over 40 years [34, 70]

Iron overload further exacerbates the condition by stimulating cell proliferation, thereby advancing endometriosis (26, 27)

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