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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

5a)) were set up

This is harmless and does not indicate the treatment is ineffective

Crohn's Disease and Celiac Disease: Both of these inflammatory conditions can damage the terminal ileumthe very last section of the small intestine where B12 absorption happens