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Encyclopedia of Biological Chemistry

Routinely activated p53 regulates cell cycle arrest and induces apoptosis to suppress cancer growth (Kastenhuber and Lowe, 2017)

We then added the PKA pathway inhibitor H89 to mimic the effect of A2ARi in compromising activated T cell survival (Supplemental Figure 6, G and H) while upregulating GSH metabolic genes ( gclc , gclm , and gpx4 ) (Supplemental Figure 6I)