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19 Iron containing proteins are also involved in a number of other cellular processes including xenobiotic transformation, the excretion of organic compounds, nucleic acid replication and repair, and cellular signaling

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People with one copy of C677T and one copy of A1298C (compound heterozygotes) may experience more significant metabolic challenges

Recently, choline has emerged as a promising possible modifier of the genomic sequence that modulates gene expression by affecting the concentration of SAM, which is the main cellular methyl donor molecule participating in epigenetic mechanisms such as DNA and histone methylation [21]