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J Trace Elem Med Biol 32:195199 Combs Jr

Recommended Baseline Tests Comprehensive metabolic panel CBC with differential Thyroid panel (TSH, free T4) Baseline subjective cognitive assessment Blood pressure (Semax can transiently elevate BP) Liver function if using Cerebrolysin long-term Key Safety Notes Semax: may increase irritability at high doses Selank: generally very safe, mild sedation possible Dihexa: extremely potent start low, go slow Noopept: headache common at high doses (choline deficit) Avoid combining multiple BDNF-elevating compounds without guidance Most lack long-term human safety data Frequently Asked Questions Is Semax legal in the US