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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

Hence, maintaining adequate zinc levels is vital for supporting neutrophil function in the elderly, as these cells play a key role in the immune defense

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Therefore, SQORs influence on ferroptosis in cancer depends on tumor metabolic demands and the immune microenvironment: it may help tumor cells survive by preventing ferroptosis, or alternatively enhance anti-tumor immunity by permitting some oxidative damage