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A large-scale lifespan analysis using eight hundred mice demonstrated that DR only in the period of 3-24 months can extend lifespan, although the mortality rate is acutely increased upon swapping diet-restricted animals to normal chow 7

Pancreatic cancer cell growth was enhanced in ATM-deficient cells when mice maintained a functional immune system, although this effect was not observed in non-obese diabetic (NOD) scid (NSG) mice

Treatment with Ana to inhibit post-chemotherapy inflammation significantly increased the half-life of PRMT1 and markedly suppressed its ubiquitination (Fig