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Using electroencephalography to measure the mices brain activity, the team also discovered that JB2 normalized neuronal excitability, or how neurons respond to stimuli with an electric charge, and seizure susceptibility

39 During antigen-induced activation of NF-B signaling in T or B cells, IKK is phosphorylated in response to stimulus-dependent conformational changes or oligomerization activation, which may be related to NEMO