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The agonist TUG469 ameliorates neurodegeneration and motor impairment both in vitro and in animal models of PD by downregulating the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome [66]

Other reports, however, propose that an increase in plasma or serum MMA during pregnancy is normal and does not reflect a low vitamin B12 status and caution that serum MAA may not be a reliable biomarker of vitamin B12 status among pregnant women (Bae et al., 2015)

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PloS ONE 8 , e78190 (2013)