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Negative regulation of hypoxia-inducible genes by the von hippel-lindau protein

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The lipid metabolomics analysis highlighted the PPARa signaling pathway as a key focus of our investigation, we further demonstrated that PPARa participates in TSCI-induced neuronal ferroptosis, because the PPARa agonist Fenofibrate significantly reduced the lipid peroxidation level and thus promoted neuronal survival as well as the axon

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