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However, under excessive or repetitive strain, calcium overload through TRPV4 and Piezo1 triggers activation of NADPH oxidase (NOX) enzymes and mitochondrial ROS production, leading to oxidative damage, inflammatory gene expression, and cell apoptosis (Swain and Liddle, 2021)

Probiotics can enhance HPV clearance through immune regulation, competitive elimination of pathogens, and production of protective metabolites (Porcaro et al., 2025)

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Argolini LM, Frontini G, Elefante E, Saccon F, Binda V, Tani C, Scotti I, Carli L, Gatto M, Esposito C, Gerosa M (2021) Multicentric study comparing cyclosporine, mycophenolate mofetil and azathioprine in the maintenance therapy of lupus nephritis: 8 years follow up