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Objective physiological data gathered from skin biopsies in this same study showed that after approximately six months of targeted supplementation with L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate, 73% of the patients demonstrated a measurable increase in calf epidermal nerve fiber density

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Scattered anecdotal reports from unsupervised users mention mild GI upset and fatigue, but without controlled data theres no way to separate the compounds own effects from dosing errors or impurities in unregulated products