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The impact of dark circles extends beyond aesthetics, affecting psychological well-being, quality of life, and economic factors

Sanchez et al

In vivo evidence corroborates this finding, such that mice with an ApoE4 background display an over 10x higher HSV-1 load in the brain compared to mice with an ApoE3 background, strikingly with viral DNA also being detected in the ovaries, spinal cord and trigeminal ganglia in infected ApoE4 mice (Burgos et al., 2006)