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10.1016/j.jstrokecerebrovasdis.2010.03.009 255 van GroenT.PuurunenK.MkiH.-M.SiveniusJ.JolkkonenJ

Nous proposons galement des solutions de conditionnement personnalisables afin de rpondre aux exigences spcifiques des hpitaux et des marchs internationaux

By means of molecular engineering, mutating the specific alanine in glutamate dehydrogenase substrate-binding pocket into glycine and / or mutating the specific valine in glutamate dehydrogenase substrate-binding pocket into alanine, the present invention has obtained NADPH-specific glutamate dehydrogenase mutants with high enzyme activity in catalyzing the substrate 2-oxo-4-[(hydroxy)(methyl)phosphinoyl]butyric acid or its salt for L-phosphinothricin preparation or NADH-specific glutamate dehydrogenase mutants with catalytic activity toward PPO