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Troseid M et al (2015) Microbiota-dependent metabolite trimethylamine- N -oxide is associated with disease severity and survival of patients with chronic heart failure

OVX, while removing androgens produced by the ovarian theca cells, also entails near total loss of circulating estradiol, which would have significant impact on adiposity and skeletal atrophy

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The diagnostic approach, therefore, should follow the path of those neurodegenerative diseases, like Alzheimers disease (AD) for example, and less of toward disease with simple diagnostic cut-off using blood-based biomarker, such as diabetes mellitus, wherein diagnostic confirmation, monitoring treatment response, as well as prognostication can be done using a clear cut-off point of plasma glucose levels