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Description

Cell Stress Chaperones 24:493502

This pathway start promotes migration of healing cells to injury sites, enhances cell adhesion necessary for tissue organization, and supports proper cytoskeletal function during tissue repair

The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)