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Eltrombopag (Promacta) is a small molecule that binds to and activates the thrombopoietin receptor

Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells

For example, if you just knock it out in mice, meaning you delete the gene for it so they dont possess a Sigma-1 receptor, they have a pretty interesting response