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2018, 9, 113, doi:10.3389/fneur.2018.00887

Discovery of QCA570 as an exceptionally potent and efficacious proteolysis targeting chimera (PROTAC) degrader of the bromodomain and extra-terminal (BET) proteins capable of inducing complete and durable tumor regression

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Importantly, ERCC1 (Excision Repair Cross-Complementing group 1) and XPF (Xeroderma Pigmentosum complementation group F) are essential proteins for both the NER and HR pathway