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The diets used for mouse studies were also isocaloric and contained the same amount of total amino acids (Supplementary Table 2)

PMID 17699297

Agonists targeting the receptors of Acrp30 not only inhibit the proliferation of thyroid cancer cells but also suppress intracellular amino acid metabolism and glucose metabolism [199]

For example: Folate (B9) Depletion: Excess B12 may reduce folate absorption, leading to hyperhomocysteinemiaa condition linked to oxidative stress and follicle damage