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also found that the occurrence of cuproptosis was significantly related to mitochondrial metabolism, providing a more plausible mechanism for explaining the anti-cancer effect of ES depending on the transport of extracellular copper ions and the mitochondrial respiration intensity of cancer cells (13)

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Yet, the precise spatiotemporal causal sequence among these three elements remains unconfirmed by longitudinal human studies

Additionally, white adipose tissue produces an excess of aromatase, which is responsible for converting androgenic hormones into estrogen, further elevating its plasma concentrations