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Notably, Vitamin C can kill cancer cells , enhancing its role in cellular protection

In good alignment, HIF-1 formed during hypoxia inhibits fatty acid -oxidation, which is critical for cancer progression 311,312 , further resulting in lipid droplet accumulation commonly observed in many solid tumors 295

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In T cell activation, glutamine deprivation has been shown to alter the activation of naive CD4 + T cells and result in their differentiation into forkhead box P3-positive (Foxp3 + ) regulatory T (T reg ) cells, which have suppressor functions 109