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One of the substrate molecules forms a series of hydrogen bonding interactions with Ser104, Thr106, Ser138, Ser139, and Asn140 of subunit A, with Thr186 and His187 of subunit B, and Ser318, Ser319, Lys324, and Asn326 of subunit C, while the other one forms equivalent hydrogen bonds with the corresponding residues of subunits B, A, D [288]