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Historically, hydroquinone (HQ) 4% as monotherapy, but also in combination with tretinoin and topical steroids (triple cream), has been an established topical, first-line treatment over years, but concerns about its side effects (permanent depigmentation, ochronosis, potential risk of cancer due to its metabolites) have prompted the use of potentially safer alternatives and the withdrawal of HQ in many countries

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Therefore, to address this critical gap, we designed a comprehensive preclinical study to dissect the specific effects of Retatrutide on adipose tissue in a model of high-fat diet (HFD)-induced obesity

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