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For instance, unprocessed NFKB2 (p100) may be induced by acute TCR signaling and could function as an inhibitor of RelB, thereby limiting Treg expansion until inflammatory, TNF receptor-mediated signaling activates the processing of p100 into p52

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A study published in PLOS ONE demonstrated that topical application of a tetravalent peptide resolved eczema in mouse models within 14 days, restoring normal epidermal morphology