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Deletion of the key catalytic enzyme methylthioadenosine phosphorylase (MTAP) gene is associated with the sensitivity of GSK3368715, 331 and a current phase II clinical study of GSK3368715 in breast cancer has been enrolled (NCT04676516) (Table 1)

It was also found that the peritoneal fluid of endometriosis patients contains high concentrations of various OS markers such as MDA, pro-inflammatory cytokines (interleukin-6 (IL-6), TNF-, transforming growth factor- (TGF-) and IL-1), angiogenic factors (IL-8 and VEGF), neural growth factor and oxidized LDL (ox-LDL) (155, 156)

For example, chronic treatment with MK-801 promotes hyperthermia and hyperlocomotion 15,16,17

Dietary supplementation with N-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial