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However, an important drawback is that the results of studies performed in small animals are of limited applicability to human beings due to their varying size and anatomy of the liver and their faster metabolism [17]

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Suicide risk is high due to poor quality of life, with one example of a patient completely bed-bound for years who felt isolated, struggled with severe exhaustion and pain, often unable to speak or have the cognitive energy to focus, consequently deciding to end her life [19]

Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson's disease