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NRF2 has been recently investigated only on two polymorphisms of the gene promoter restricted to the Asian population so that the number of published results is still preliminary to define a strong association between the NRF2 SNPs and the disease (Song et al

Competing interests The authors declare that they had no competing interests

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It includes: Chaste tree berry (Vitex) and polygonum, herbs traditionally used to support healthy hormonal signaling DIM to support beneficial estrogen metabolism and aromatase activity Calcium-D-glucarate to promote proper estrogen elimination, which is especially important for people with endometriosis Antioxidant protection through resveratrol to support cellular health 13 B vitamins, including B6, B12, and folate, which are involved in cell differentiation and methylation pathways Magnesium and calcium to support bone health, muscle function, and overall hormone balance Who can benefit most: Those with signs of estrogen dominance or impaired estrogen clearance People looking for targeted hormonal and antioxidant support rather than a generic multivitamin Anyone managing endometriosis alongside fatigue, hormonal imbalance, or nutrient depletion Findings from one case-controlled study 14 showed that intakes of calcium, potassium, vitamins B12, B2, B6, and C are inversely related to the risk 15 of endometriosismeaning the more you consume of these nutrients, the better protection you have