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Similarly, piperine reduced the growth and motility of TNBC cell lines by causing cell cycle arrest, upregulating the expression of the cyclin-dependent kinase inhibitor p21, blocking Akt signaling, and initiating caspase-dependent apoptosis

There were no differences in urine volume, so water intake was likely not drastically different between groups

FDG PET Imaging Procedure FDG-PET was performed according to standard clinical protocol using the Siemens mMR PET-MRI scanner (Siemens Medical Solutions USA, Malvern, PA)