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Emerging evidence suggests that HO-1 exerts a regulatory function in the pathophysiological process of VaD by modulating the ferroptosis pathway (Fu et al., 2023

Heidari M, Johnstone DM, Bassett B, Graham RM, Chua A, House MJ, Collingwood JF, Bettencourt C, Houlden H, Ryten M (2016) Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

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FIGURE 9 The tissue sections of the heart from all groups, including the control, sham, I/R, I/R + GSH, I/R + GO@GSH, and I/R + GO@GSH-FA, showed normal myocardial architecture without any signs of inflammation, necrosis, or other pathological changes