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The high subgroup heterogeneity primarily reflects considerable diversity within the cognitive impairment group regarding aetiology (e.g., AD, PD, and MCI), disease severity, and comorbidities

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Reaction mixture was filtered, concentrated and crude product was purified by flash chromatography (silica gel, hexanes/EtOAc) to provide (,S)-4-nitrophenyl 2,6-bis(tert- butoxycarbonylamino) hexanoate (548.7 mg, 55%)