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Cabeza-Cabrerizo M, Cardoso A, Minutti CM, Pereira da Costa M, Reis e Sousa C

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The disease is highly heritable with gene association studies implicating genes that encode polymorphisms in extracellular matrix (ECM) molecules (e.g., MMP, HSP70, NOS3) or ocular development (the Frizzled related MFRP protein, hepatocyte growth factor HGF)