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Pragmatic trials embedded within routine care could assess adherence, patient acceptability, and integration with diverse cultural dietary practices

In cellular and animal models of steroid insensitivity mediated by oxidative stress, S-CMC restored steroid sensitivity by increasing HDAC-2 expression/activity through elevating GSH and SOD levels, reducing oxidative stress, enhancing HDAC-2 recruitment and reducing H4 acetylation in the IL-8 promoter region, and eventually alleviating inflammation and lung damage [88, 89]

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Moreover, aged mice have been shown to be more susceptible to the release of proinflammatory cytokines and DNA oxidation from the same CS exposure than young mice with proper robust adaptive responses [16]