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Up to 20% of people over 60 may become deficient according to UCLA Health (2022), and the National Institutes of Health estimates that 10 to 30% of older adults cannot absorb naturally occurring vitamin B12 from food

Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

Other Health Benefits of B12 In addition to getting B12 shots for weight loss, people also get them to help their bodies function more effectively in other ways

Low levels can cause: Tingling or numbness in hands and feet Difficulty walking or balance problems Muscle weakness Memory problems Poor concentration Mood changes (depression, irritability) Cognitive decline in severe cases Other B12 deficiency signs Sore or red tongue Mouth ulcers Vision disturbances Dizziness Cold hands and feet Causes of Vitamin B12 Deficiency Vitamin B12 deficiency happens either due to low intake or poor absorption