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Unlike clotting factors, which promptly restore balance in the coagulation cascade at the point of deficiency or bridge activated Factor IX and Factor X to restore the function of missing activated Factor VIII, [348] allowing for stable blood clot formation and hemostasis, the gene therapies do not directly integrate into the coagulation cascade

The solution must be maintained in a cool, dark place and shielded from heat and direct sunlight

Train Both Clinical and Non-Clinical Team Members Give injectors and clinical staff detailed protocol training, including screening and documentation

Treatment duration is generally limited to 812 weeks before cycling off to evaluate response [9]