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Tricarboxylic acid (TCA) cycle intermediates in the urine, which reflect metabolic changes in the diabetic kidney, may be potential prognostic biomarkers for the progression of DKD (2)

It is appropriate to append modifier 25 to ED codes 99281-99285 when these services lead to a decision to perform diagnostic medical/surgical and/or therapeutic medical/surgical procedure(s) The bottom line is to maximize your efficiency seeing patients and maximize their convenience in your medical home by providing medically necessary E/M 25 services at the time of another significant and separate E/M service or procedure

Another example of a primary astrocytopathy is the frontotemporal lobar degeneration or Picks dementia, leading to progressive loss of memory, primary progressive aphasia, and social misbehaviour

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