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19 This can increase susceptibility of intestinal permeability (leaky gut), allowing harmful substances to enter the bloodstream and trigger systemic inflammation

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Moreover, several potential target proteins of DZXI related to cell signaling and synaptic chemical transmission, including PDE10A, PRKCG, and GRIA1, were predicted to have a high binding affinity to DZXI main compounds

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The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier

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