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A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan

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This includes: People whove already had at least one fracture People who have low bone density (that is, they have a T-score of -2.8 or lower on a bone mineral density test) People who continue to experience bone loss despite taking other bone-strengthening medications (for example, those who need to take steroids over the long term) Side Effects and Safety Anabolic medications are considered safe, but as with any drug, there is always a risk of side effects

Those with severe or long-term issues often increase their dose later