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From the results of the present and other studies it is clear that the application of PEF technology to appropriately hydrated seeds has the potential to modify the growth and stress responses of the resultant seedlings, and providing the correct parameters are chosen, PEF treatment of seeds can cause significant and sustained changes in seedling metabolism

Sekhar conceived the hypotheses, designed the trial, obtained funding, developed the GlyNAC intervention, recruited and consented subjects, supervised Premranjan Kumar and Chun Liu, interpreted data, and wrote the manuscript

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4-1BB costimulation ameliorates t cell exhaustion induced by tonic signaling of chimeric antigen receptors