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However, there are significant gaps in our understanding, including determining optimal dosages for efficacy and safety, elucidating precise mechanisms of action, establishing clinical efficacy through more large-scale trials, developing personalized treatment approaches, and studying the longstanding effects of vitamin supplementation in cancer patients

These fibers also send collateral projections to the deep cerebellar nuclei and engage inhibitory interneurons, including basket and stellate cells, which promote lateral inhibition of neighboring Purkinje cells (48, 49)

This is the common, diagnosed cause of B12 deficiency in the UK