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Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71

The non-classical pyroptosis pathway is mediated by caspase-4/5 (human) or caspase-11 (mouse), which directly senses cytoplasmic LPS and cleaves GSDMD, often subsequently leading to activation of the NLRP3-caspase-1 axis, thereby amplifying the inflammatory response

International Journal of Medical Sciences 17 (6): 751761

Horky, P