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Swisher SG , Roth JA, Komaki R, Gu J, Lee JJ, Hicks M, Ro JY, Hong WK, Merritt JA, Ahrar K, Atkinson NE, Correa AM, Dolormente M, Dreiling L, El-Naggar AK, Fossella F, Francisco R, Glisson B, Grammer S, Herbst R, Huaringa A, Kemp B, Khuri FR, Kurie JM, Liao Z, McDonnell TJ, Morice R, Morello F, Munden R, Papadimitrakopoulou V, Pisters KM, Putnam JB Jr, Sarabia AJ, Shelton T, Stevens C, Shin DM, Smythe WR, Vaporciyan AA, Walsh GL, Yin M

doi: 10.1089/met.2010.0020 131 CruzKJMoraisJBde OliveiraARSeveroJSMarreiroDD

Under extreme iodine exposure, the thyroid gland may also exhibit aberrant expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its death receptor (DR)-5, resulting in follicular cell apoptosis

Here, lower maintenance doses of 3-5 mg, three times per week, sustained over months and cycled appropriately, may be more aligned with the goal than high-frequency maximum doses