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described that GHK significantly increased the expression of DNA repair genes, while 47 genes are stimulated and five genes are suppressed [35]

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An increased ratio of succinate to -KG in cancers resulting from impaired succinate dehydrogenase (SDH) activity is related to pervasive DNA hypermethylation, which contributes to the downregulation of key genes implicated in cell differentiation and cancer stages 102

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