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As a result, a hypertonic solution obtained by adding 100 mOsm.l 1 of mannitol to isotonic PBS medium (Mannitol, osmolarity increased to ~400 mOsm.l 1 without modification of ion concentrations) greatly decreased MSU and CPP crystal-induced IL-1 production (200 g/ml, 3 h, Fig

Due to high toxicity of the compound the genetic end points were not noted for strain D7

However, the elimination of publication bias using trim and fill analysis revealed that NAC also could decrease E2 levels and endometrial thickness

Sativex produced no statistically significant improvement in either the mean daily pain scores (primary outcome measure) or quality-of-life assessments (secondary outcome measures)